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Weinstein claims that these changes with sodium amytal occurred only in the brain-damaged individuals; whereas, in nonbrain-damaged individuals receiving sodium amytal, the subjects talked of illness in terms of a third person, used more "concrete" symbols, selectively misinterpreted questions about illness, and misnamed the examiners in "paraphasic" fashion. Hoch, Cattell, and Pennes (64, 65) administered sodium amytal, pervitin, and mescaline to each of sixteen patients suffering from the pseudo neurotic form of schizophrenia, twenty-four patients with an overt form of schizophrenia with slight. With these drugs, especially with mescaline, they found typical physiologic changes occurring, mainly involving the vegetative nervous system. However, with most patients, some aspects of the drug experience seemed to be a direct continuation of previous personality factors. For instance, a patient who showed obsessive compulsive features before the drug experiment would tend to show the same obsessive structure while intoxicated. The same was true about anxiety attitudes, intellectualizations of conflicts, preoccupations with artistic, philosophical, or other matters. Although Beringer () in his drug studies, using mescaline, did not find any correlation between personality and drug reaction, Stockings (122) found that cyclothymic and schizothymic individuals re- -107- sponded differently. Bensheim (15) thought that the cyclothymic group responded with euphoria and depression to mescaline and the schizothymic group with ecstasy. Guttman and MacClay (59) and Sarwer-Foner (118) also found correlations between personality and drug reactions. It is perhaps of interest here that Russian scientists have also emphasized the differential response of different types of individuals to drugs, specifically chlorpromazine (86). It has been obvious to those who listen to and study people with personality disorders that the verbal behavior of an individual suffering from an emotional disorder is relatively peculiar, both in form and in content. The hysteric and schizophrenic are quite variable in the duration and length of their remarks. There are typical thematic and structural characteristics of the speech habits of patients with these types of psychiatric disorders. Years of intensive research are needed to supply some of this unavailable knowledge. However, it is already acknowledged that individuals with features of hysterical, conversion, or dissociative reactions are likely to be suggestible and to react strongly to all psychopharmacologic agents, including placebos (83, 85). Drugs may tend to reinforce the need to give for individuals burdened with feelings of neurotic shame and guilt, especially if such feelings are enhanced by the interrogator. Drugs may also furnish the needed excuse and relief from personal responsibility for sources who violate internalized values and loyalties in revealing information.

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Assessment and analeptic and anti anesthesial action promising substances was conducted on mice in accordance with accepted standards. The initial screening of original pharmacological substances for the analeptic action performed on the model of ketamin anesthesia, after which was set optimal effective dose and acute toxicity (intravenously intraperitoneally and oral) of substances leader. Study features analeptic action of the given substance scheduled in comparison with caffeine niketamid, sulfokamfokayin and other substances in various models of anesthesia (viadril, tiopental, hexenal) and the model of alcohol intoxication. Further experiments include determining the best mode of application, installation dose dependency, regimen in a single system and use the most effective substance. The research helped to choose the leader of the substance with a pronounced awakening effect. Derivatives of sulfur and nitrogen-containing heterocyclic were looking to find new analeptics. The class of peptidergic neuroprotector and nootropic drugs attracts particular attention. Previous research allowed to reveal their neuroprotectivе and nootropic properties. The study is aimed to found st nd rd the influence of neuropeptides on the 1 , 2 and 3 memory stages in mice. Amnesia has been reproduced by scopolamine intraperitoneal injection at a dose of 1. The anti-amnestic activity (AaA) of neuropeptides was calculated with the Battler formula. All neuropeptides and reference drug semax show statistically significant influence on the amnesia caused by scopolamine administration. It st nd appear in the improving of memory encoding (1 memory stage), storage (2 rd memory stage) and retrieval (3 memory stage). At the conditions of scopolamine-induced amnesia investigated rd neuropeptides stimulates 3 memory stage too. This activity increases in the sequence semax < КК-10 = КК-1 < КК-2 < КК-3 = КК-5.

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10 of 10 - Review by V. Cronos
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Total customer reviews: 174